"The Painting That Started The Renaissance"
Masaccio
Holy Trinity
Tomasso Masaccio' Holy Trinity is cited by some as being the first painting of the Renaissance. It is a fresco in Santa Maria Novella in Florence.
From Wikipedia:
The fresco had a transforming effect on generations of Florentine painters and visiting artists.
Masaccio
Holy Trinity detail
Masaccio
Holy Trintiy detail: Memento mori skeleton